Order Number Global Mapper 14 High Quality

Another study was done by Holtgrewe et al. [31], where the focus was the sensitivity of the tools. They enumerated the possible matching intervals with a maximum distance k for each read. Afterwards, they evaluated the sensitivity of the mappers according to the number of intervals they detected. Holtgrewe et al. used the suggested sensitivity evaluation criteria to evaluate the performance of SOAP2, Bowtie, BWA, and Shrimp2 on both simulated and real datasets. However, they used small reference genomes (the S. cerevisiae genome of length 12 Mbp and the D. melanogaster genome of length 169 Mbp). In addition, the experiments were performed on small real data sets of 10,000 reads. For evaluating the performance of the tools on real data sets, Holtgrewe et al. used RazerS to detect the possible matching intervals. RazerS is a full sensitive mapper, hence it is a very slow mapper [21]. Therefore, scaling the suggested benchmark process for realistic whole genome mapping experiments with millions of reads is not practical. Nevertheless, after the initial submission of this work, RazerS3 [26] was published, thus, making a significant improvement in the running time of the evaluation process.

Order Number Global Mapper 14